Winner Analytik Jena Science Award 2020 Winner in the Category of “Best Scientific Paper in the Area of Chemical Analysis”

Winner in the Category of “Best Scientific Paper in the Area of Chemical Analysis”

Dr. Daniel Bäcker, Pharmaceutical Chemistry, University of Innsbruck

Fluorination as tool to improve bioanalytical sensitivity and COX-2-selective antitumor activity of cobalt alkyne complexes

Justification: "The authors⁽ⁱ⁾ describe their research on oncologically relevant active substances with antitumor-active metal complexes and aspirin as a substructure. They examined the influence of fluorination on improvements in bioanalytical sensitivity and selective antitumor activity.
Cobalt in [(prop-2-ynyl) -2-acetoxybenzoate] dicobalt hexacarbonyl (Co-ASS) was selected as a promising example, and as usual, microtiter plate technology was used for cell culture experiments, enzyme immunoassays, and other experiments.
The amounts of cobalt in the cultivated cells were quantified using High-Resolution Continuum Source AAS in the contrAA 700 ⁽¹⁾ with a graphite oven. However, deviating from this, the amounts of fluorine present as GaF were also determined using High-Resolution Continuum Source MAS in the contrAA 700 with a modified graphite oven protocol.
It was shown that the HR-CS MAS technology is a highly sensitive method for the quantification of fluorinated cobalt complexes.
In the future, this approach could potentially become particularly suitable for the analysis of other fluorinated substances in biological samples.
This work builds an impressive bridge between the biochemical and cytological methods and atomic absorption spectrometry.
It also indicates that microtiter plate technology is becoming increasingly important for AAS"

^{(1) Is also feasible using the new devices of the contrAA product line.}

<sup>(i) Daniel Bäcker,a Victoria Obermoser,a Elisabeth Anna Kirchner,a Andrea Hupfauf,a Brigitte Kircher ORCID,bc Ronald Gust ORCID,*a
* Corresponding authors
a Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI – Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB – Center for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria
b Immunobiology and Stem Cell Laboratory, Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Anichstraße 35, 6020 Innsbruck, Austria
c Tyrolean Cancer Research Institute, Innrain 66, 6020 Innsbruck, Austria</sup>

The paper was published in "Dalton Transactions" 2019 .