BetaPrion HUMAN ELISA

ELISA for total human prion protein

Product Details

  • Quantitative determination of total prion protein in human CSF, serum or plasma
  • Reproducible 6-point standard curve using lyophilized standards and controls
  • Flexible application depending on sample throughput: Standardized ELISA-Format on 12 x 8 immunostrips
  • For research use only!

The BetaPrion Human ELISA is designed to detect and quantify the level of total prion protein in human cerebrospinal fluid (CSF), serum, or plasma samples. The BetaPrion Human ELISA is for research use only and not intended as a diagnostic test.

Specifications

Target

  • human total prion protein

Starting material

CSF, serum, plasma

Detection principle

homogeneous Sandwich-ELISA

Order Information

Product nameQuantityOrder number

BetaPrion Human ELISA

96 reactions847-0104000104

 

Manufacturer:

AJ Roboscreen GmbH
Hohmannstrasse 7
04129 Leipzig
Germany
Phone: +49 341 989734 0
Fax: +49 341 989734 199

Downloads

Biomarker profiling for Neurodegenerative Diseases

Open PDF

Poster_Measurement of CSF total prion protein levels for distinguishing CJD from AD

Open PDF

References

  1. Calderón-Garcidueñas L, et al. Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents. J Alzheimers Dis. 2016 Sep 6;54(2):597-613. doi: 10.3233/JAD-160472. PMID: 27567860
  2. Villar-Piqué A, et al. Cerebrospinal Fluid Total Prion Protein in the Spectrum of Prion Diseases. Mol Neurobiol. 2019 Apr;56(4):2811-2821. doi: 10.1007/s12035-018-1251-1. Epub 2018 Jul 30. PMID: 30062673
  3. Vallabh SM, et al. Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7793-7798. doi: 10.1073/pnas.1901947116. Epub 2019 Apr 1. PMID: 30936307
  4. Abu Rumeileh S, et al. Diagnostic Accuracy of a Combined Analysis of Cerebrospinal Fluid t-PrP, t-tau, p-tau, and Aβ42 in the Differential Diagnosis of Creutzfeldt-Jakob Disease from Alzheimer's Disease with Emphasis on Atypical Disease Variants. J Alzheimers Dis. 2017;55(4):1471-1480. doi: 10.3233/JAD-160740. PMID: 27886009
  5. Dorey A, et al. Association of cerebrospinal fluid prion protein levels and the distinction between Alzheimer disease and Creutzfeldt-Jakob disease. JAMA Neurol. 2015 Mar;72(3):267-75. doi: 10.1001/jamaneurol.2014.4068. PMID: 25559883

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